This study conducts a comparative analysis of seismic performance in the context of enhancing earthquake resilience, focusing on fixed base and base isolated reinforced concrete structures. Earthquakes pose a significant threat to infrastructure and human safety, making it imperative to investigate innovative strategies for mitigating their impact. Through comprehensive simulations, testing, and analytical methods, this research assesses the seismic response of both fixed base and base isolated structures under varying seismic conditions. The study aims to provide valuable insights into the efficacy of base isolation techniques and their potential for enhancing earthquake resilience in critical infrastructure.